Endothelial Cell Activation by Hemodynamic Shear Stress Derived from 4 Arteriovenous Fistula for Hemodialysis Access
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چکیده
Address for correspondence: 31 Prof. Andrea Remuzzi, Eng.D. 32 Department of Biomedical Engineering 33 IRCCS Istituto di Ricerche Farmacologiche Mario Negri 34 Via Stezzano, 87 35 24126 Bergamo, Italy 36 Tel. +39 (35) 4213311 37 Fax +39 (35) 4213299 38 E-mail: [email protected] 39 40 Articles in PresS. Am J Physiol Heart Circ Physiol (October 23, 2015). doi:10.1152/ajpheart.00098.2015
منابع مشابه
Endothelial cell activation by hemodynamic shear stress derived from arteriovenous fistula for hemodialysis access.
Intimal hyperplasia (IH) is the first cause of failure of an arteriovenous fistula (AVF). The aim of the present study was to investigate the effects on endothelial cells (ECs) of shear stress waveforms derived from AVF areas prone to develop IH. We used a cone-and-plate device to obtain real-time control of shear stress acting on EC cultures. We exposed human umbilical vein ECs for 48 h to dif...
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BACKGROUND A patent arteriovenous (AV) fistula induces activation of regional vascular endothelium and vascular shear force. Shear stress is an important physiological force in mobilizing endothelial progenitor cells (EPCs). This study aimed to explore the perioperative changes of circulating EPC levels for patients who require hemodialysis and underwent radiocephalic fistula operation. METHO...
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BACKGROUND An autogenous arteriovenous fistula is the optimal vascular access for hemodialysis. In the case of brachiocephalic fistula, cephalic arch stenosis commonly develops leading to access failure. We have hypothesized that a contribution to fistula failure is low wall shear stress resulting from post-fistula creation hemodynamic changes that occur in the cephalic arch. METHODS Twenty-t...
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In Taiwan, more than 85% of patients with end-stage renal disease undergo maintenance hemodialysis (HD). The native arteriovenous fistula (AVF) accounts for a prevalence of more than 80% of the vascular access in our patients. Some mechanical factors may affect the patency of hemodialysis vascular access, such as surgical skill, puncture technique and shear stress on the vascular endothelium. S...
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تاریخ انتشار 2015